Epalrestat increases glutathione, thioredoxin, and heme oxygenase-1 by stimulating Nrf2 pathway in endothelial cells

Epalrestat increases glutathione, thioredoxin, and heme oxygenase-1 by stimulating Nrf2 pathway in endothelial cells

Epalrestat (EPS) is the only aldose reductase inhibitor that is currently available for the treatment of diabetic neuropathy. Recently, we found that EPS at near-plasma concentration increases the intracellular levels of glutathione (GSH) in rat Schwann cells. GSH plays a crucial role in protecting...

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Bibliographic Details
Main Authors: Kaori Yama, Keisuke Sato, Natsuki Abe, Yu Murao, Ryosuke Tatsunami, Yoshiko Tampo
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Redox Biology
Subjects:
Epalrestat
Endothelial cell
Glutathione
Heme oxygenase-1
Thioredoxin
Nuclear factor erythroid 2-related factor 2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714001268

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http://www.sciencedirect.com/science/article/pii/S2213231714001268

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