Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential.

Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential.

Recombinant alkaline phosphatases are becoming promising protein therapeutics to prevent skeletal mineralization defects, inflammatory bowel diseases, and treat acute kidney injury. By substituting the flexible crown domain of human intestinal alkaline phosphatase (IAP) with that of the human placen...

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Bibliographic Details
Main Authors: Tina Kiffer-Moreira, Campbell R Sheen, Kellen Cristina da Silva Gasque, Mayte Bolean, Pietro Ciancaglini, Andrea van Elsas, Marc F Hoylaerts, José Luis Millán
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3933536?pdf=render

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http://europepmc.org/articles/PMC3933536?pdf=render

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