The Transcriptional and Protein Profile From Human Infected Neuroprogenitor Cells Is Strongly Correlated to Zika Virus Microcephaly Cytokines Phenotype Evidencing a Persistent Inflammation in the CNS

The Transcriptional and Protein Profile From Human Infected Neuroprogenitor Cells Is Strongly Correlated to Zika Virus Microcephaly Cytokines Phenotype Evidencing a Persistent Inflammation in the CNS

Zika virus (ZIKV) infection during pregnancy is associated with microcephaly, a congenital malformation resulting from neuroinflammation and direct effects of virus replication on the developing central nervous system (CNS). However, the exact changes in the affected CNS remain unknown. Here, we sho...

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Main Authors: Morganna C. Lima, Leila R. de Mendonça, Antonio M. Rezende, Raquel M. Carrera, Conceição E. Aníbal-Silva, Matthew Demers, Leonardo D'Aiuto, Joel Wood, Kodavali V. Chowdari, Michael Griffiths, Antonio R. Lucena-Araujo, Manoel Barral-Netto, Elisa A. N. Azevedo, Renan W. Alves, Pablo C. S. Farias, Ernesto T. A. Marques, Priscila M. S. Castanha, Claire L. Donald, Alain Kohl, Vishwajit L. Nimgaonkar, Rafael F. O. Franca
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
Zika virus
central nervous system
inflammation
type-I interferon
interferonopathy
microcephaly
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01928/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01928/full

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