Dystrophin R16/17 protein therapy restores sarcolemmal nNOS in trans and improves muscle perfusion and function

Dystrophin R16/17 protein therapy restores sarcolemmal nNOS in trans and improves muscle perfusion and function

Abstract Background Delocalization of neuronal nitric oxide synthase (nNOS) from the sarcolemma leads to functional muscle ischemia. This contributes to the pathogenesis in cachexia, aging and muscular dystrophy. Mutations in the gene encoding dystrophin result in Duchenne muscular dystrophy (DMD) a...

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Bibliographic Details
Main Authors: Junling Zhao, Hsiao Tung Yang, Lakmini Wasala, Keqing Zhang, Yongping Yue, Dongsheng Duan, Yi Lai
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Molecular Medicine
Subjects:
Dystrophin R16/17
Blood perfusion
Protein therapy
Sarcolemmal nNOS
Functional ischemia
Dystrophinopathy
Online Access:http://link.springer.com/article/10.1186/s10020-019-0101-6

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http://link.springer.com/article/10.1186/s10020-019-0101-6

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