Zinc Inhibits HIF-Prolyl Hydroxylase Inhibitor-Aggravated VSMC Calcification Induced by High Phosphate

Zinc Inhibits HIF-Prolyl Hydroxylase Inhibitor-Aggravated VSMC Calcification Induced by High Phosphate

Vascular calcification is a life-threatening clinical condition in chronic kidney disease (CKD) and is associated with reduced zinc serum levels. Anemia is another frequent complication of CKD. Hypoxia-inducible factor (HIF) stabilizers, also known as HIF prolyl hydroxylase inhibitors (PHI), are pro...

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Bibliographic Details
Main Authors: Annamária Nagy, Dávid Pethő, Tamás Gáll, Erzsébet Zavaczki, Mónika Nyitrai, József Posta, Abolfazl Zarjou, Anupam Agarwal, György Balla, József Balla
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Physiology
Subjects:
VSMC
vascular calcification
phosphate
Zn supplementation
Pi
prolyl hydroxylase inhibitor
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01584/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01584/full

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