Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury

Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury

Abstract Background Traumatic brain injury (TBI) is a major cause of CNS neurodegeneration and has no disease-altering therapies. It is commonly associated with a specific type of biomechanical disruption of the axon called traumatic axonal injury (TAI), which often leads to axonal and sometimes per...

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Bibliographic Details
Main Authors: Derek S. Welsbie, Nikolaos K. Ziogas, Leyan Xu, Byung-Jin Kim, Yusong Ge, Amit K. Patel, Jiwon Ryu, Mohamed Lehar, Athanasios S. Alexandris, Nicholas Stewart, Donald J. Zack, Vassilis E. Koliatsos
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Molecular Neurodegeneration
Subjects:
Traumatic axonal injury
Concussion
Cell death
Traumatic brain injury
Optic neuropathy
Dual leucine zipper kinase
Online Access:http://link.springer.com/article/10.1186/s13024-019-0345-1

Internet

http://link.springer.com/article/10.1186/s13024-019-0345-1

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