Development and validation of the quantitative determination of avapritinib in rat plasma by a bioanalytical method of UPLC-MS/MS

Development and validation of the quantitative determination of avapritinib in rat plasma by a bioanalytical method of UPLC-MS/MS

Avapritinib, an orally consumed, highly selective inhibitor of platelet-derived growth factor receptor alpha (PDGFRA), is approved in the USA for PDGFRA exon 18 (including D842V) mutant gastrointestinal stromal tumour (GIST). The research conducted investigates an advanced reliable and fast UPLC-MS/...

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Bibliographic Details
Main Authors: Xuegu Xu, Shunbin Luo, Qiang Yang, Yingjie Wang, Wenlong Li, Guanyang Lin, Ren-ai Xu
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Arabian Journal of Chemistry
Subjects:
Avapritinib
Sample
Pharmacokinetics
UPLC-MS/MS
Rat plasma
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535221001672

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http://www.sciencedirect.com/science/article/pii/S1878535221001672

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