The BARD1 Cys557Ser variant and breast cancer risk in Iceland.

The BARD1 Cys557Ser variant and breast cancer risk in Iceland.

Most, if not all, of the cellular functions of the BRCA1 protein are mediated through heterodimeric complexes composed of BRCA1 and a related protein, BARD1. Some breast-cancer-associated BRCA1 missense mutations disrupt the function of the BRCA1/BARD1 complex. It is therefore pertinent to determine...

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Bibliographic Details
Main Authors: Simon N Stacey, Patrick Sulem, Oskar T Johannsson, Agnar Helgason, Julius Gudmundsson, Jelena P Kostic, Kristleifur Kristjansson, Thora Jonsdottir, Helgi Sigurdsson, Jon Hrafnkelsson, Jakob Johannsson, Thorarinn Sveinsson, Gardar Myrdal, Hlynur Niels Grimsson, Jon T Bergthorsson, Laufey T Amundadottir, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong, Kari Stefansson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-07-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC1479388?pdf=render

Internet

http://europepmc.org/articles/PMC1479388?pdf=render

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