The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10

The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10

Minichromosome maintenance protein 10 (Mcm10) is essential for DNA unwinding by the replisome during S phase. It is emerging as a promising anti-cancer target as MCM10 expression correlates with tumour progression and poor clinical outcomes. Here we used a competition-based fluorescence polarization...

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Bibliographic Details
Main Authors: Carolyn N. Paulson, Kristen John, Ryan M. Baxley, Fredy Kurniawan, Kayo Orellana, Rawle Francis, Alexandra Sobeck, Brandt F. Eichman, Walter J. Chazin, Hideki Aihara, Gunda I. Georg, Jon E. Hawkinson, Anja-Katrin Bielinsky
Format: Article
Language:English
Published: The Royal Society 2019-08-01
Series:Open Biology
Subjects:
mcm10
fluorescence polarization
suramin
rpa70
surface plasmon resonance
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.190117

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.190117

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