Targeting hypoxia in tumor: a new promising therapeutic strategy

Abstract Low oxygen condition (hypoxia) is considered a hallmark of rapidly growing solid tumors. The presence of hypoxia renders tumor cells resistant to conventional chemo- and radio-therapy, selecting a more malignant and invasive phenotype and playing a negative role in patient prognosis. This c...

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Bibliographic Details
Main Authors: Maria Carla Bosco, Gabriella D’Orazi, Donatella Del Bufalo
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HIF
VHL
Online Access:https://doi.org/10.1186/s13046-019-1517-0