Comparison of nuisance parameters in pediatric versus adult randomized trials: a meta-epidemiologic empirical evaluation

Comparison of nuisance parameters in pediatric versus adult randomized trials: a meta-epidemiologic empirical evaluation

Abstract Background We wished to compare the nuisance parameters of pediatric vs. adult randomized-trials (RCTs) and determine if the latter can be used in sample size computations of the former. Methods In this meta-epidemiologic empirical evaluation we examined meta-analyses from the Cochrane Data...

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Bibliographic Details
Main Authors: Ben Vandermeer, Ingeborg van der Tweel, Marijke C. Jansen-van der Weide, Stephanie S. Weinreich, Despina G. Contopoulos-Ioannidis, Dirk Bassler, Ricardo M. Fernandes, Lisa Askie, Haroon Saloojee, Paola Baiardi, Susan S. Ellenberg, Johanna H. van der Lee
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Medical Research Methodology
Subjects:
Nuisance parameters
Extrapolation
Sample size computations
Pediatric trials
Adult trials
Online Access:http://link.springer.com/article/10.1186/s12874-017-0456-8

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http://link.springer.com/article/10.1186/s12874-017-0456-8

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