Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters

Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters

The liver and its zonation contribute to whole body homeostasis. Acute and chronic, not always liver, diseases impair proper metabolic zonation. Various underlying pathways, such as β-catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradien...

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Bibliographic Details
Main Author: Thomas Kietzmann
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
ROS
antioxidants
antioxidative enzymes
matrix
diet
fibrosis
homeostasis
hypoxia
HIF
liver
metabolic zonation
metabolism
morphogen signaling
optimization
pathology
regulatory network
sinusoid
Hepatocytes
Online Access:https://www.mdpi.com/1422-0067/20/9/2347

Internet

https://www.mdpi.com/1422-0067/20/9/2347

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