Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters

The liver and its zonation contribute to whole body homeostasis. Acute and chronic, not always liver, diseases impair proper metabolic zonation. Various underlying pathways, such as β-catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradien...

Full description

Bibliographic Details
Main Author:	Thomas Kietzmann
Format:	Article
Language:	English
Published:	MDPI AG 2019-05-01
Series:	International Journal of Molecular Sciences
Subjects:	ROS antioxidants antioxidative enzymes matrix diet fibrosis homeostasis hypoxia HIF liver metabolic zonation metabolism morphogen signaling optimization pathology regulatory network sinusoid Hepatocytes
Online Access:	https://www.mdpi.com/1422-0067/20/9/2347

id	doaj-51676ca0988b4ab0b2f351feaa452481
record_format	Article
spelling	doaj-51676ca0988b4ab0b2f351feaa4524812020-11-25T01:58:58ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-05-01209234710.3390/ijms20092347ijms20092347Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert MastersThomas Kietzmann0Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, FinlandThe liver and its zonation contribute to whole body homeostasis. Acute and chronic, not always liver, diseases impair proper metabolic zonation. Various underlying pathways, such as β-catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradient, appear to be contributors. Interestingly, hypoxia and hypoxia-inducible transcription factors can orchestrate those pathways. In the current review, we connect novel findings of liver zonation in health and disease and provide a view about the dynamic interplay between these different pathways and cell-types to drive liver zonation and systemic homeostasis.https://www.mdpi.com/1422-0067/20/9/2347ROSantioxidantsantioxidative enzymesmatrixdietfibrosishomeostasishypoxiaHIFlivermetabolic zonationmetabolismmorphogen signalingoptimizationpathologyregulatory networksinusoidHepatocytes
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Thomas Kietzmann
spellingShingle	Thomas Kietzmann Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters International Journal of Molecular Sciences ROS antioxidants antioxidative enzymes matrix diet fibrosis homeostasis hypoxia HIF liver metabolic zonation metabolism morphogen signaling optimization pathology regulatory network sinusoid Hepatocytes
author_facet	Thomas Kietzmann
author_sort	Thomas Kietzmann
title	Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters
title_short	Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters
title_full	Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters
title_fullStr	Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters
title_full_unstemmed	Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters
title_sort	liver zonation in health and disease: hypoxia and hypoxia-inducible transcription factors as concert masters
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2019-05-01
description	The liver and its zonation contribute to whole body homeostasis. Acute and chronic, not always liver, diseases impair proper metabolic zonation. Various underlying pathways, such as β-catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradient, appear to be contributors. Interestingly, hypoxia and hypoxia-inducible transcription factors can orchestrate those pathways. In the current review, we connect novel findings of liver zonation in health and disease and provide a view about the dynamic interplay between these different pathways and cell-types to drive liver zonation and systemic homeostasis.
topic	ROS antioxidants antioxidative enzymes matrix diet fibrosis homeostasis hypoxia HIF liver metabolic zonation metabolism morphogen signaling optimization pathology regulatory network sinusoid Hepatocytes
url	https://www.mdpi.com/1422-0067/20/9/2347
work_keys_str_mv	AT thomaskietzmann liverzonationinhealthanddiseasehypoxiaandhypoxiainducibletranscriptionfactorsasconcertmasters
_version_	1724966887448641536

Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters

Similar Items