Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters
The liver and its zonation contribute to whole body homeostasis. Acute and chronic, not always liver, diseases impair proper metabolic zonation. Various underlying pathways, such as β-catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradien...
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doaj-51676ca0988b4ab0b2f351feaa4524812020-11-25T01:58:58ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-05-01209234710.3390/ijms20092347ijms20092347Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert MastersThomas Kietzmann0Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, FinlandThe liver and its zonation contribute to whole body homeostasis. Acute and chronic, not always liver, diseases impair proper metabolic zonation. Various underlying pathways, such as β-catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradient, appear to be contributors. Interestingly, hypoxia and hypoxia-inducible transcription factors can orchestrate those pathways. In the current review, we connect novel findings of liver zonation in health and disease and provide a view about the dynamic interplay between these different pathways and cell-types to drive liver zonation and systemic homeostasis.https://www.mdpi.com/1422-0067/20/9/2347ROSantioxidantsantioxidative enzymesmatrixdietfibrosishomeostasishypoxiaHIFlivermetabolic zonationmetabolismmorphogen signalingoptimizationpathologyregulatory networksinusoidHepatocytes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thomas Kietzmann |
spellingShingle |
Thomas Kietzmann Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters International Journal of Molecular Sciences ROS antioxidants antioxidative enzymes matrix diet fibrosis homeostasis hypoxia HIF liver metabolic zonation metabolism morphogen signaling optimization pathology regulatory network sinusoid Hepatocytes |
author_facet |
Thomas Kietzmann |
author_sort |
Thomas Kietzmann |
title |
Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters |
title_short |
Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters |
title_full |
Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters |
title_fullStr |
Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters |
title_full_unstemmed |
Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters |
title_sort |
liver zonation in health and disease: hypoxia and hypoxia-inducible transcription factors as concert masters |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-05-01 |
description |
The liver and its zonation contribute to whole body homeostasis. Acute and chronic, not always liver, diseases impair proper metabolic zonation. Various underlying pathways, such as β-catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradient, appear to be contributors. Interestingly, hypoxia and hypoxia-inducible transcription factors can orchestrate those pathways. In the current review, we connect novel findings of liver zonation in health and disease and provide a view about the dynamic interplay between these different pathways and cell-types to drive liver zonation and systemic homeostasis. |
topic |
ROS antioxidants antioxidative enzymes matrix diet fibrosis homeostasis hypoxia HIF liver metabolic zonation metabolism morphogen signaling optimization pathology regulatory network sinusoid Hepatocytes |
url |
https://www.mdpi.com/1422-0067/20/9/2347 |
work_keys_str_mv |
AT thomaskietzmann liverzonationinhealthanddiseasehypoxiaandhypoxiainducibletranscriptionfactorsasconcertmasters |
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