Structure and Function of HLA-A*02-Restricted Hantaan Virus Cytotoxic T Cell Epitope that Mediates Effective Protective Responses in HLA-A2.1/Kb Transgenic Mice

Structure and Function of HLA-A*02-Restricted Hantaan Virus Cytotoxic T Cell Epitope that Mediates Effective Protective Responses in HLA-A2.1/Kb Transgenic Mice

Hantavirus infections cause severe emerging diseases in humans and are associated with high mortality rates; therefore, they have become a global public health concern. Our previous study showed that the CD8+ T-cell epitope aa129-aa137 (FVVPILLKA, FA9) of the Hantaan virus (HTNV) nucleoprotein (NP),...

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Bibliographic Details
Main Authors: Ying Ma, Lin-Feng Cheng, Bin Yuan, Yusi Zhang, Chunmei Zhang, Yun Zhang, Kang Tang, Ran Zhuang, Lihua Chen, Kun Yang, Fanglin Zhang, Boquan Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Immunology
Subjects:
Hantaan virus
crystal structure
HLA-A*02
Cytotoxic T cell epitope
CD8+ T cell response
HLA-A2.1/Kb transgenic mice
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00298/full

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http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00298/full

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