Theoretical Insights into the Biophysics of Protein Bi-stability and Evolutionary Switches.

Deciphering the effects of nonsynonymous mutations on protein structure is central to many areas of biomedical research and is of fundamental importance to the study of molecular evolution. Much of the investigation of protein evolution has focused on mutations that leave a protein's folded str...

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Bibliographic Details
Main Authors: Tobias Sikosek, Heinrich Krobath, Hue Sun Chan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-06-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4890782?pdf=render