Independent Origin of Plasmodium falciparum Antifolate Super-Resistance, Uganda, Tanzania, and Ethiopia

Independent Origin of Plasmodium falciparum Antifolate Super-Resistance, Uganda, Tanzania, and Ethiopia

Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine–pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps and the triple-mutant Pfdhfr. Using samples c...

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Bibliographic Details
Main Authors: Michael Alifrangis, Sidsel Nag, Mette L. Schousboe, Deus S. Ishengoma, John Lusingu, Hirva Pota, Reginald A. Kavishe, Richard Pearce, Rosalynn Ord, Caroline Lynch, Seyoum Dejene, Jonathan Cox, John Rwakimari, Daniel T.R. Minja, Martha M. Lemnge, Cally Roper
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2014-08-01
Series:Emerging Infectious Diseases
Subjects:
Dihydrofolate reductase
Pfdhfr
dihydropteroate synthetase
Pfdhps
581
eastern Africa
Online Access:https://wwwnc.cdc.gov/eid/article/20/8/13-1897_article

Internet

https://wwwnc.cdc.gov/eid/article/20/8/13-1897_article

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