Conserved epitopes with high HLA-I population coverage are targets of CD8+ T cells associated with high IFN-γ responses against all dengue virus serotypes

Conserved epitopes with high HLA-I population coverage are targets of CD8+ T cells associated with high IFN-γ responses against all dengue virus serotypes

Abstract Cytotoxic CD8+ T cells are key for immune protection against viral infections. The breadth and cross-reactivity of these responses are important against rapidly mutating RNA viruses, such as dengue (DENV), yet how viral diversity affect T cell responses and their cross-reactivity against mu...

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Bibliographic Details
Main Authors: Thiruni N. Adikari, Francesca Di Giallonardo, Preston Leung, Alba Grifoni, Alex Sette, Daniela Weiskopf, Rowena A. Bull, Fabio Luciani
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-77565-2

Internet

https://doi.org/10.1038/s41598-020-77565-2

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