The Proteasome Activator PA28γ, a Negative Regulator of p53, Is Transcriptionally Up-Regulated by p53

The Proteasome Activator PA28γ, a Negative Regulator of p53, Is Transcriptionally Up-Regulated by p53

PA28γ (also called REGγ, 11Sγ or PSME3) negatively regulates p53 activity by promoting its nuclear export and/or degradation. Here, using the RNA ligase-mediated rapid amplification of cDNA ends (RLM-RACE) method, we identified the transcription start site of the PA28γ gene. Assessment with the luci...

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Bibliographic Details
Main Authors: Zhen-Xing Wan, Dong-Mei Yuan, Yi-Ming Zhuo, Xin Yi, Ji Zhou, Zao-Xu Xu, Jian-Lin Zhou
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:International Journal of Molecular Sciences
Subjects:
PA28γ
p53
promoter
transcription regulation
PSME3
negative feedback regulation
Online Access:http://www.mdpi.com/1422-0067/15/2/2573

Internet

http://www.mdpi.com/1422-0067/15/2/2573

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