Primary Aldosteronism: Metabolic Reprogramming and the Pathogenesis of Aldosterone-Producing Adenomas

Primary Aldosteronism: Metabolic Reprogramming and the Pathogenesis of Aldosterone-Producing Adenomas

Aldosterone-producing adenomas (APAs) are characterized by aldosterone hypersecretion and deregulated adrenocortical cell growth. Increased energy consumption required to maintain cellular tumorigenic properties triggers metabolic alterations that shape the tumor microenvironment to acquire necessar...

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Bibliographic Details
Main Authors: Siyuan Gong, Martina Tetti, Martin Reincke, Tracy Ann Williams
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
adaptive metabolism
adrenal gland
conn adenoma
fatty acid metabolism
ferroptosis
hyperaldosteronism
Online Access:https://www.mdpi.com/2072-6694/13/15/3716

Internet

https://www.mdpi.com/2072-6694/13/15/3716

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