Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP

Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP

Mutations in two related genes,presenilin 1andpresenilin 2(PS1andPS2), cosegregate with Alzheimer's disease. PS1 and PS2 are highly homologous polytopic membrane proteins that are subject to endoproteolytic cleavagein vivo.The resulting N- and C-terminal derivatives are the preponderant PS-rela...

Full description

Bibliographic Details
Main Authors: Gopal Thinakaran, Jean B. Regard, Christopher M.L. Bouton, Christie L. Harris, Donald L. Price, David R. Borchelt, Sangram S. Sisodia
Format: Article
Language:English
Published: Elsevier 1998-01-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996198901711

Internet

http://www.sciencedirect.com/science/article/pii/S0969996198901711

Similar Items