Enhanced Development of Azoxymethane-Induced Colonic Preneoplastic Lesions in Hypertensive Rats

Enhanced Development of Azoxymethane-Induced Colonic Preneoplastic Lesions in Hypertensive Rats

Metabolic syndrome is associated with an increased risk of colorectal cancer. This study investigated the impact of hypertension, a component of metabolic syndrome, on azoxymethane (AOM)-induced colorectal carcinogenesis using SHRSP/Izm (SHRSP) non-diabetic/hypertensive rats and SHRSP.Z-Leprfa/IzmDm...

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Bibliographic Details
Main Authors: Takuji Tanaka, Hisashi Tsurumi, Yohei Shirakami, Masaya Kubota, Takafumi Sumi, Atsushi Baba, Tomohiko Ohno, Masahito Shimizu, Takahiro Kochi, Hisataka Moriwaki
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:International Journal of Molecular Sciences
Subjects:
hypertension
colon carcinogenesis
oxidative stress
inflammation
angiotensin-II
Online Access:http://www.mdpi.com/1422-0067/14/7/14700

Internet

http://www.mdpi.com/1422-0067/14/7/14700

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