Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway.

Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway.

<h4>Background and aims</h4>Nitric oxide-independent soluble guanylyl cyclase (sGC) activators reactivate the haem-oxidized enzyme in vascular diseases. This study was undertaken to investigate the anti-platelet mechanisms of the haem-independent sGC activator BAY 60-2770 in human washed...

Full description

Bibliographic Details
Main Authors: Camila B Mendes-Silverio, Luiz O S Leiria, Rafael P Morganti, Gabriel F Anhê, Sisi Marcondes, Fabíola Z Mónica, Gilberto De Nucci, Edson Antunes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144808/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144808/?tool=EBI

Similar Items