N-Oleoylglycine and N-Oleoylalanine Do Not Modify Tolerance to Nociception, Hyperthermia, and Suppression of Activity Produced by Morphine

N-Oleoylglycine and N-Oleoylalanine Do Not Modify Tolerance to Nociception, Hyperthermia, and Suppression of Activity Produced by Morphine

The endogenous amide N-Oleoylglycine (OlGly) and its analog N-Oleoylalanine (OlAla), have been shown to interfere with the affective and somatic responses to acute naloxone-precipitated MWD in male rats. Here we evaluated the potential of a single dose (5 mg/kg, ip) which alleviates withdrawal of th...

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Bibliographic Details
Main Authors: Erin M. Rock, Cheryl L. Limebeer, Megan T. Sullivan, Marieka V. DeVuono, Aron H. Lichtman, Vincenzo Di Marzo, Raphael Mechoulam, Linda A. Parker
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
N-oleoylglycine
N-oleoylalanine
morphine
tolerance
analgesia
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2021.620145/full

Internet

https://www.frontiersin.org/articles/10.3389/fnsyn.2021.620145/full

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