Morpholino Oligomer-Induced Dystrophin Isoforms to Map the Functional Domains in the Dystrophin Protein

Morpholino Oligomer-Induced Dystrophin Isoforms to Map the Functional Domains in the Dystrophin Protein

Dystrophin plays a crucial role in maintaining sarcolemma stability during muscle contractions, and mutations that prevent the expression of a functional protein cause Duchenne muscular dystrophy (DMD). Antisense oligonucleotide-mediated manipulation of pre-messenger RNA splicing to bypass Duchenne-...

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Bibliographic Details
Main Authors: Dunhui Li, Abbie M. Adams, Russell D. Johnsen, Susan Fletcher, Steve D. Wilton
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Duchenne muscular dystrophy
dystrophin isoforms
antisense oligonucleotides
splice-switching
exon skipping
phosphorodiamidate morpholino oligomer
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302481

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http://www.sciencedirect.com/science/article/pii/S2162253120302481

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