Remodeling of energy metabolism and absence of electrophysiological changes in hearts of obese hyperleptinemic mice. New insights into the pleiotropic role of leptin

Remodeling of energy metabolism and absence of electrophysiological changes in hearts of obese hyperleptinemic mice. New insights into the pleiotropic role of leptin

Dietary treatment with high-fat diets (HFD) triggers diabetes and hyperleptinemia, concomitantly with a partial state of leptin resistance that affects hepatic and adipose tissue but not the heart. In this context, characterized by widespread steatosis, cardiac lipid content remains unchanged. As pr...

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Bibliographic Details
Main Authors: Rocío eGuzmán-Ruiz, Nieves eGómez-Hurtado, Marta eGil-Ortega, M Carmen Gonzalez, Isabel eAránguez, Miriam eMartín-Ramos, Carmen eGonzález-Martín, Carmen eDelgado, María S Fernández-Alfonso, Mariano eRuiz-Gayo
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Endocrinology
Subjects:
Cardiac Electrophysiology
Leptin
Obesity
cardiac metabolism
UCP3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00175/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00175/full

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