Strong interferon-gamma mediated cellular immunity to scrub typhus demonstrated using a novel whole cell antigen ELISpot assay in rhesus macaques and humans.

Strong interferon-gamma mediated cellular immunity to scrub typhus demonstrated using a novel whole cell antigen ELISpot assay in rhesus macaques and humans.

Scrub typhus is a febrile infection caused by the obligate intracellular bacterium Orientia tsutsugamushi, which causes significant morbidity and mortality across the Asia-Pacific region. The control of this vector-borne disease is challenging due to humans being dead-end hosts, vertical maintenance...

Full description

Bibliographic Details
Main Authors: Manutsanun Sumonwiriya, Daniel H Paris, Piyanate Sunyakumthorn, Tippawan Anantatat, Kemajittra Jenjaroen, Suchintana Chumseng, Rawiwan Im-Erbsin, Ampai Tanganuchitcharnchai, Suthatip Jintaworn, Stuart D Blacksell, Fazle R Chowdhury, Barbara Kronsteiner, Prapit Teparrukkul, Robin L Burke, Eric D Lombardini, Allen L Richards, Carl J Mason, James W Jones, Nicholas P J Day, Susanna J Dunachie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-09-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5608426?pdf=render

Internet

http://europepmc.org/articles/PMC5608426?pdf=render

Similar Items