Structural Prediction of the Dimeric Form of the Mammalian Translocator Membrane Protein TSPO: A Key Target for Brain Diagnostics

Structural Prediction of the Dimeric Form of the Mammalian Translocator Membrane Protein TSPO: A Key Target for Brain Diagnostics

Positron emission tomography (PET) radioligands targeting the human translocator membrane protein (TSPO) are broadly used for the investigations of neuroinflammatory conditions associated with neurological disorders. Structural information on the mammalian protein homodimers—the suggested...

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Bibliographic Details
Main Authors: Juan Zeng, Riccardo Guareschi, Mangesh Damre, Ruyin Cao, Achim Kless, Bernd Neumaier, Andreas Bauer, Alejandro Giorgetti, Paolo Carloni, Giulia Rossetti
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
TSPO
radioligands
PET
oligomerization
brain inflammation
homology modeling
molecular dynamics
docking
Online Access:http://www.mdpi.com/1422-0067/19/9/2588

Internet

http://www.mdpi.com/1422-0067/19/9/2588

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