ProNGF derived from rat sciatic nerves downregulates neurite elongation and axon specification in PC12 cells

ProNGF derived from rat sciatic nerves downregulates neurite elongation and axon specification in PC12 cells

Several reports have shown that a sciatic nerve conditioned media (CM) causes neuronal-like differentiation in PC12 cells. This differentiation is featured by neurite outgrowth, which are exclusively dendrites, without axon or sodium current induction. In previous studies, our group reported that th...

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Bibliographic Details
Main Authors: Anna Sofia Trigos, Marines eLongart, Lisbeth eGarcia, Cecilia eCastillo, Patricia eForsyth, Rafael eMedina
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Axons
PC12 Cells
Sodium Channels
neuronal differentiation
sortilin
conditioned medium
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00364/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00364/full

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