The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells

The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells

The small GTPase RHOJ is a key regulator of breast cancer metastasis by promoting cell migration and invasion. The prometastatic stimulus TGF-β activates RHOJ transcription via megakaryocytic leukemia 1 (MKL1). The underlying epigenetic mechanism is not clear. Here, we report that MKL1 deficiency le...

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Bibliographic Details
Main Authors: Ziyu Zhang, Baoyu Chen, Yuwen Zhu, Tianyi Zhang, Xiaoling Zhang, Yibiao Yuan, Yong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
transcriptional regulation
epigenetics
histone demethylase
breast cancer cell
histone methylation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.664375/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.664375/full

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