Synthesis and Antiviral Activity of 5‑(4‑Chlorophenyl)-1,3,4-Thiadiazole Sulfonamides

Synthesis and Antiviral Activity of 5‑(4‑Chlorophenyl)-1,3,4-Thiadiazole Sulfonamides

Starting from 4-chlorobenzoic acid, 10 new 5-(4-chlorophenyl)-N-substituted-N-1,3,4-thiadiazole-2-sulfonamide derivatives were synthesized in six-steps. Esterification of 4-chlorobenzoic acid with methanol and subsequent hydrazination, salt formation and cyclization afforded 5-(4-chlorophen-yl)-1,3,...

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Bibliographic Details
Main Authors: Yuping Zhang, De-Yu Huang, Pinaki S. Bhadury, Weiming Xu, Huitao Fan, Song Yang, Keming Liu, Zhuo Chen
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Molecules
Subjects:
sulfonamide derivatives
1,3,4-thiadiazole moiety
synthesis
antiviral activity
Online Access:http://www.mdpi.com/1420-3049/15/12/9046/

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http://www.mdpi.com/1420-3049/15/12/9046/

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