Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines

Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines

Tissue-resident macrophages play critical roles in controlling homeostasis, tissue repair, and immunity. Inflammatory macrophages can sustain tissue damage and promote the development of fibrosis during infections and sterile tissue injury. The NLRP3 inflammasome and its effector cytokine IL-1&#...

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Bibliographic Details
Main Authors: Nilay Köse-Vogel, Sven Stengel, Elena Gardey, Tatiana Kirchberger-Tolstik, Philipp A. Reuken, Andreas Stallmach, Tony Bruns
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cells
Subjects:
inflammation
macrophages
innate immunity
innate immune memory
histones
epigenetics
Online Access:https://www.mdpi.com/2073-4409/9/1/79

Internet

https://www.mdpi.com/2073-4409/9/1/79

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