Neferine Ameliorates Sepsis-Induced Myocardial Dysfunction Through Anti-Apoptotic and Antioxidative Effects by Regulating the PI3K/AKT/mTOR Signaling Pathway

Neferine Ameliorates Sepsis-Induced Myocardial Dysfunction Through Anti-Apoptotic and Antioxidative Effects by Regulating the PI3K/AKT/mTOR Signaling Pathway

Septic cardiomyopathy is a common complication of severe sepsis, which is one of the leading causes of death in intensive care units. Therefore, finding an effective therapy target is urgent. Neferine is an alkaloid extracted from the green embryos of mature seeds of Nelumbo nucifera Gaertn., which...

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Bibliographic Details
Main Authors: Zhen Qi, Renrong Wang, Rongheng Liao, Song Xue, Yongyi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
neferine
apoptosis
oxidative stress
mitochondria
lipopolysaccharide
cardiac dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.706251/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.706251/full

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