Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2

Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2

<p>Abstract</p> <p>Background</p> <p>PC cell-derived growth factor (PCDGF), also called epithelin/granulin precursor (GEP), is an 88-kDa secreted glycoprotein with the ability to stimulate cell proliferation in an autocrine fashion. In addition, some studies indicated t...

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Bibliographic Details
Main Authors: Zhou Jianfeng, Wang Shixuan, Wu Mingfu, Han Zhiqiang, Chen Gang, Wang Beibei, Tian Xun, Wang Wei, Liao Guoning, Xi Ling, Liu Yulan, Xu Gang, Lu Yunping, Ma Ding
Format: Article
Language:English
Published: BMC 2007-01-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/7/22

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http://www.biomedcentral.com/1471-2407/7/22

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