<i>KRAS</i> Promoter G-Quadruplexes from Sequences of Different Length: A Physicochemical Study

<i>KRAS</i> Promoter G-Quadruplexes from Sequences of Different Length: A Physicochemical Study

DNA G-quadruplexes (G4s) form in relevant genomic regions and intervene in several biological processes, including the modulation of oncogenes expression, and are potential anticancer drug targets. The human <i>KRAS</i> proto-oncogene promoter region contains guanine-rich sequences able...

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Bibliographic Details
Main Authors: Federica D’Aria, Bruno Pagano, Luigi Petraccone, Concetta Giancola
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
<i>KRAS</i> G-quadruplex
CD spectroscopy
differential scanning calorimetry
thermodynamic stability
Online Access:https://www.mdpi.com/1422-0067/22/1/448

Internet

https://www.mdpi.com/1422-0067/22/1/448

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