A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis.

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis.

In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of disabling symptoms. Myocardin Related Transcrip...

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Bibliographic Details
Main Authors: Xu Shiwen, Richard Stratton, Joanna Nikitorowicz-Buniak, Bahja Ahmed-Abdi, Markella Ponticos, Christopher Denton, David Abraham, Ayuko Takahashi, Bela Suki, Matthew D Layne, Robert Lafyatis, Barbara D Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4425676?pdf=render

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http://europepmc.org/articles/PMC4425676?pdf=render

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