Association of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease

Association of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease

Abstract Background Follicular helper CD4+ T (Tfh) cells have a critical role in IgG4 production by B cells in IgG4-related disease (IgG4-RD). Recent studies including ours showed that SLAMF7+CD4+ T cells are an important pathological driver of IgG4-RD. In this study, we have sought to elucidate a r...

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Bibliographic Details
Main Authors: Kazuhiko Higashioka, Yuri Ota, Takashi Maehara, Masafumi Moriyama, Masahiro Ayano, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Takahiko Horiuchi, Seiji Nakamura, Koichi Akashi, Hiroaki Niiro
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Immunology
Subjects:
SLAMF7
IgG4-RD
Follicular helper T cells
IL-21
IL-10
B cells
Online Access:http://link.springer.com/article/10.1186/s12865-020-00361-0

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http://link.springer.com/article/10.1186/s12865-020-00361-0

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