Targeting the Class A Carbapenemase GES-5 via Virtual Screening

Targeting the Class A Carbapenemase GES-5 via Virtual Screening

The worldwide spread of β-lactamases able to hydrolyze last resort carbapenems contributes to the antibiotic resistance problem and menaces the successful antimicrobial treatment of clinically relevant pathogens. Class A carbapenemases include members of the KPC and GES families. While drug...

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Bibliographic Details
Main Authors: Raphael Klein, Laura Cendron, Martina Montanari, Pierangelo Bellio, Giuseppe Celenza, Lorenzo Maso, Donatella Tondi, Ruth Brenk
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Biomolecules
Subjects:
antibiotic resistance
ges-5
guyana extended-spectrum-β-lactamase
carbapenemase
virtual screening
docking
noncovalent inhibition
Online Access:https://www.mdpi.com/2218-273X/10/2/304

Internet

https://www.mdpi.com/2218-273X/10/2/304

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