Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability

Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability

Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has been shown to be present at synapses and to induce hyperexcitability in mouse knock-in brain regions vulnerable to AD. Apo...

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Bibliographic Details
Main Authors: Sabine C. Konings, Laura Torres-Garcia, Isak Martinsson, Gunnar K. Gouras
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neuroscience
Subjects:
Apolipoprotein E
Alzheimer’s disease
synapse
neuron
astrocyte
amyloid
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.734001/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.734001/full

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