Exploring the Impact of PARK2 Mutations on the Total and Mitochondrial Proteome of Human Skin Fibroblasts

Exploring the Impact of PARK2 Mutations on the Total and Mitochondrial Proteome of Human Skin Fibroblasts

Mutations in PARK2 gene are the most frequent cause of familial forms of Parkinson’s disease (PD). This gene encodes Parkin, an E3 ubiquitin ligase involved in several cellular mechanisms, including mitophagy. Parkin loss-of-function is responsible for the cellular accumulation of damaged mitochondr...

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Main Authors: Mara Zilocchi, Ilaria Colugnat, Marta Lualdi, Monica Meduri, Federica Marini, Victor Corasolla Carregari, Mohamed Taha Moutaoufik, Sadhna Phanse, Luisa Pieroni, Mohan Babu, Barbara Garavaglia, Mauro Fasano, Tiziana Alberio
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
proteomic alterations
interactome
mitophagy
mitochondria
Parkinson’s Disease
Parkin (PARK2)
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00423/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00423/full

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