Cordycerebroside A suppresses VCAM-dependent monocyte adhesion in osteoarthritis synovial fibroblasts by inhibiting MEK/ERK/AP-1 signaling

Cordycerebroside A suppresses VCAM-dependent monocyte adhesion in osteoarthritis synovial fibroblasts by inhibiting MEK/ERK/AP-1 signaling

Osteoarthritis (OA) is characterized by the infiltration and adhesion of monocyte into the joint synovium. Vascular cell adhesion molecule 1 (VCAM-1) is a critical cell adhesion molecule that controls monocyte motility during OA progression. Cordycerebroside A, a cerebroside compound isolated from C...

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Bibliographic Details
Main Authors: Hsiang-Ping Lee, Shan-Chi Liu, Yu-Han Wang, Bo-Cheng Chen, Hsien-Te Chen, Te-Mao Li, Wei-Chien Huang, Chin-Jung Hsu, Yang-Chang Wu, Chih-Hsin Tang
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Journal of Functional Foods
Subjects:
Cordycerebroside A
Osteoarthritis
VCAM-1
Monocyte adhesion
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621003613

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http://www.sciencedirect.com/science/article/pii/S1756464621003613

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