Cell penetrable humanized-VH/V(H)H that inhibit RNA dependent RNA polymerase (NS5B) of HCV.

Cell penetrable humanized-VH/V(H)H that inhibit RNA dependent RNA polymerase (NS5B) of HCV.

NS5B is pivotal RNA dependent RNA polymerase (RdRp) of HCV and NS5B function interfering halts the virus infective cycle. This work aimed to produce cell penetrable humanized single domain antibodies (SdAb; VH/V(H)H) that interfere with the RdRp activity. Recombinant NS5BΔ55 of genotype 3a HCV with...

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Bibliographic Details
Main Authors: Kanyarat Thueng-in, Jeeraphong Thanongsaksrikul, Potjanee Srimanote, Kunan Bangphoomi, Ornnuthchar Poungpair, Santi Maneewatch, Kiattawee Choowongkomon, Wanpen Chaicumpa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3493538?pdf=render

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http://europepmc.org/articles/PMC3493538?pdf=render

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