Genomic-Scale Interaction Involving Complementary Sequences in the Hepatitis C Virus 5′UTR Domain IIa and the RNA-Dependent RNA Polymerase Coding Region Promotes Efficient Virus Replication

Genomic-Scale Interaction Involving Complementary Sequences in the Hepatitis C Virus 5′UTR Domain IIa and the RNA-Dependent RNA Polymerase Coding Region Promotes Efficient Virus Replication

The hepatitis C virus (HCV) genome contains structured elements thought to play important regulatory roles in viral RNA translation and replication processes. We used in vitro RNA binding assays to map interactions involving the HCV 5′UTR and distal sequences in NS5B to examine their impac...

Full description

Bibliographic Details
Main Authors: Elodie Rance, Jerome E. Tanner, Caroline Alfieri
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Viruses
Subjects:
NS5B
secondary structure
circular RNA
RNA folding
RNA stem-loop
HCV IRES
long-distance RNA–RNA interaction
Flaviviridae
Online Access:http://www.mdpi.com/1999-4915/11/1/17

Internet

http://www.mdpi.com/1999-4915/11/1/17

Similar Items