Assessment of the Role of C3(H2O) in the Alternative Pathway

Assessment of the Role of C3(H2O) in the Alternative Pathway

In this study we investigate the hydrolysis of C3 to C3(H2O) and its ability to initiate activation via the alternative pathway (AP) of the complement system. The internal thioester bond within C3 is hydrolyzed by water in plasma because of its inherent lability. This results in the formation of non...

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Bibliographic Details
Main Authors: Karin Fromell, Anna Adler, Amanda Åman, Vivek Anand Manivel, Shan Huang, Claudia Dührkop, Kerstin Sandholm, Kristina N. Ekdahl, Bo Nilsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
complement
C3
C3(H2O)
C3b
alternative pathway
C3 convertase
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00530/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00530/full

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