Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress.

Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress.

From bacteria to humans, individual cells within isogenic populations can show significant variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate this, we used single-cell RNA sequencing to quantify transcript heterogeneity in single Saccharomyces cerevisiae...

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Bibliographic Details
Main Authors: Audrey P Gasch, Feiqiao Brian Yu, James Hose, Leah E Escalante, Mike Place, Rhonda Bacher, Jad Kanbar, Doina Ciobanu, Laura Sandor, Igor V Grigoriev, Christina Kendziorski, Stephen R Quake, Megan N McClean
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2004050

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https://doi.org/10.1371/journal.pbio.2004050

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