Early active immunization with Aβ3–10-KLH vaccine reduces tau phosphorylation in the hippocampus and protects cognition of mice

Early active immunization with Aβ3–10-KLH vaccine reduces tau phosphorylation in the hippocampus and protects cognition of mice

Active and passive anti-Aβ immunotherapies have successfully been used for the prevention and treatment of Alzheimer’s disease animal models. However, clinical use of these immunotherapies is not effective, because the vaccination is administered too late. At 1 month of age, 100 μL of Aβ3–10-KLH pep...

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Bibliographic Details
Main Authors: Jin-Chun Wang, Kun Zhu, Hui-Yi Zhang, Guo-Qing Wang, Hui-Ying Liu, Yun-Peng Cao
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
3×Tg-AD; Aβ3–10-KLH vaccine; Alzheimer’s disease; amyloid precursor protein; amyloid-beta; cognitive decline; tau phosphorylation; transgenic mouse
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=3;spage=519;epage=527;aulast=Wang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=3;spage=519;epage=527;aulast=Wang

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