Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice.

Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice.

Single nucleotide polymorphisms in the gene encoding the protein tyrosine phosphatase TCPTP (encoded by PTPN2) have been linked with the development of autoimmunity. Here we have used Cre/LoxP recombination to generate Ptpn2(ex2-/ex2-) mice with a global deficiency in TCPTP on a C57BL/6 background a...

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Bibliographic Details
Main Authors: Florian Wiede, Sock Hui Chew, Catherine van Vliet, Ingrid J Poulton, Konstantinos Kyparissoudis, Tedjo Sasmono, Kim Loh, Michel L Tremblay, Dale I Godfrey, Natalie A Sims, Tony Tiganis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3348136?pdf=render

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http://europepmc.org/articles/PMC3348136?pdf=render

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