The Effects of Piper Sarmentosum Water Extract on the Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Bones with Excessive Glucocorticoids

The Effects of Piper Sarmentosum Water Extract on the Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Bones with Excessive Glucocorticoids

Background: Long-term glucocorticoid therapy causes secondary osteoporosis leading to pathological fractures. Glucocorticoid action in bone is dependant upon the activity of 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-HSD1). Piper sarmentosum is a local herb that possesses the ability to inh...

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Bibliographic Details
Main Authors: Elvy Suhana Mohd Ramli, Ima Nirwana Soelaiman, Faizah Othman, Fairus Ahmad, Ahmad Nazrun Shuib, Norazlina Mohamed, Norliza Muhammad, Farihah Hj Suhaimi
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2012-03-01
Series:Iranian Journal of Medical Sciences
Subjects:
Piper sarmentosum
11β-hydroxysteroid dehydrogenase type 1
dexamethasone
glucocorticoids
osteoporosis
Online Access:http://ijms.sums.ac.ir/files/PDFfiles/07-Dr.%20Suhaimi.pdf

Internet

http://ijms.sums.ac.ir/files/PDFfiles/07-Dr.%20Suhaimi.pdf

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