GDF11 induces differentiation and apoptosis and inhibits migration of C17.2 neural stem cells via modulating MAPK signaling pathway

GDF11, a member of TGF-β superfamily, has recently received widespread attention as a novel anti-ageing/rejuvenation factor to reverse age-related dysfunctions in heart and skeletal muscle, and to induce angiogenesis and neurogenesis. However, these positive effects of GDF11 were challenged by sever...

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Bibliographic Details
Main Authors: Zongkui Wang, Miaomiao Dou, Fengjuan Liu, Peng Jiang, Shengliang Ye, Li Ma, Haijun Cao, Xi Du, Pan Sun, Na Su, Fangzhao Lin, Rong Zhang, Changqing Li
Format: Article
Language:English
Published: PeerJ Inc. 2018-09-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/5524.pdf