Analysis of Transcriptional Regulation of the Human miR-17-92 Cluster; Evidence for Involvement of Pim-1

Analysis of Transcriptional Regulation of the Human miR-17-92 Cluster; Evidence for Involvement of Pim-1

The human polycistronic miRNA cluster miR-17-92 is frequently overexpressed in hematopoietic malignancies and cancers. Its transcription is in part controlled by an E2F-regulated host gene promoter. An intronic A/T-rich region directly upstream of the miRNA coding region also contributes to cluster...

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Bibliographic Details
Main Authors: Roland K. Hartmann, Achim Aigner, Arnold Grünweller, Dennis Streng, Julia Schlereth, Lara Golde, Kerstin Lange-Grünweller, Dorothee Hartmann, Maren Thomas
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:International Journal of Molecular Sciences
Subjects:
miRNA
miR-17-92 cluster
Pim-1
miRNA promoter
c-Myc
HP1γ
RNAi
Online Access:http://www.mdpi.com/1422-0067/14/6/12273

Internet

http://www.mdpi.com/1422-0067/14/6/12273

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