Targeting Voltage-Dependent Calcium Channels with Pregabalin Exerts a Direct Neuroprotective Effect in an Animal Model of Multiple Sclerosis

Targeting Voltage-Dependent Calcium Channels with Pregabalin Exerts a Direct Neuroprotective Effect in an Animal Model of Multiple Sclerosis

Background/Aims: Multiple sclerosis (MS) is a prototypical autoimmune central nervous system (CNS) disease. Particularly progressive forms of MS (PMS) show significant neuroaxonal damage as consequence of demyelination and neuronal hyperexcitation. Immuno-modulatory treatment strategies are benefici...

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Bibliographic Details
Main Authors: Petra Hundehege, Juncal Fernandez-Orth, Pia Römer, Tobias Ruck, Thomas Müntefering, Susann Eichler, Manuela Cerina, Lisa Epping, Sarah Albrecht, Amélie F. Menke, Katharina Birkner, Kerstin Göbel, Thomas Budde, Frauke Zipp, Heinz Wiendl, Ali Gorji, Stefan Bittner, Sven G. Meuth
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Neurosignals
Subjects:
Multiple sclerosis
Pregabalin
Experimental autoimmune encephalomyelitis
Neuroprotection
Online Access:https://www.karger.com/Article/FullText/495425

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https://www.karger.com/Article/FullText/495425

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